Biocompatibility of n-butyl-cyanoacrylate compared to conventional skin sutures in skin wounds

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Andrés Cáceres Barreno
Carlos Cava Vergiú
José Robello Malatto
Erika Alberca Ramos
Jaime Rodríguez Chessa

Resumen

Introduction: N-Butyl-cyanoacrylate is a tissue-synthesis material. It offers countless advantages: short application time, easy execution, as well as possessing hemostatic character. This material is bacteriostatic, biodegradable, and exhibits suitable tensile strength. Objective: The objective of the present paper was the histological evaluation of n-butyl-cyanoacrylate biocompatibility on rats dorsum (spine), compared to braided black silk and Polyglactin 910. Materials and Methods: Thirty six Wixtar albino rats were used for the procedure. They were randomly divided into four groups (A, B, C, D) related to the time of sacrifi ce (3rd, 7th, 14th and 21st day) respectively. On the rats’ spine, three 2 cm long incisions were performed. Histological parameters were as follows: polymorphonuclear cell inflammatory infiltrate, young fibroblasts and epidermis thickening. Results: N-butyl-cyanoacrylate caused lesser polymorphonuclear infi ltrate when compared to other used materials. Fibroblast proliferation peaked in groups treated with n-butyl-cyanoacrylate when compared to the rest. Epidermis thickening showed high mitotic ability of keratocytes to remodel epithelium. At the 14th and 21st days most tissues treated with N-Butyl-cyanoacrylate were found to be completely remodeled when compared to the rest. Conclusion: N-butyl-cyanoacrylate was shown to be the most biocompatible material, since it elicited shortest healing time.

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Cómo citar
Cáceres Barreno, A., Cava Vergiú, C., Robello Malatto, J., Alberca Ramos, E., & Rodríguez Chessa, J. (2019). Biocompatibility of n-butyl-cyanoacrylate compared to conventional skin sutures in skin wounds. Revista Odontológica Mexicana Órgano Oficial De La Facultad De Odontología UNAM, 17(2). https://doi.org/10.22201/fo.1870199xp.2013.17.2.69713
Biografía del autor/a

Andrés Cáceres Barreno

Coordinación de publicaciones.

Editora de la Revista Ódontológica Mexicana. Órgano Oficial de la Facultad de Odontología, UNAM.