Sepsis, pronóstico de gravedad y comorbilidad

Abstract

SEPSIS IS A PHYSIOPATHOLOGIC CONCEPT, THAT CONSIDERS THE INTERACTIONS BETWEEN BACTERIA AND HOST. THERE ARE MANY MEDIATORS LIKE ILK 1, IL K3, ILK 6 AND NTF´, CONDITIONING A HYPOPERFUSION SITUATION, THAT CREATES AN EMERGENCY CONDITION, WITH HIGH MORTALITY. SURVIVAL DEPENDS OF MANY FACTORS, BETWEEN THEM, THE COMORBIDITIES. THE MOST IMPORTANT ARE: RESPIRATORY, HEPATIC, KIDNEY AND CARDIAC FAILURE. THERE ARE MANY WAYS TO EVALUATE THE PROGNOSIS; THOSE CONSIDERED MOST IMPORTANT ARE THE PHYSIOLOGICAL VARIABLES AND COMORBIDITIES. UNFORTUNATELY, THERE ARE MANY FAILURES ON THE DIFFERENT INSTRUMENTS TO EVALUATE PROGNOSIS IN SEPSIS; THAT IS THE REASON WHY WE MUST REEVALUATE THE ROLE OF COMORBIDITIES IN SEPSIS.