Does brain serotonin have a role in incremental learning memory?
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Abstract
This is a brief review about the involvement of serotonin in memory consolidation. The available experimental evidence strongly suggests that, indeed, this biogenic amine participate in the storage of information derived from negatively-reinforced learning. However, the vast majority of experiments in this area of research has been carried out using systemic administration of drugs that interfere with serotonergic activity; thus, there is not a clear idea about which neural structures, which have serotonergic receptors, are involved in consolidation. Recent studies indicate that 5-HT2-type receptors of the striatum are important for memory and that in conditions of enhanced learning serotonin is not necessary for the development of learning and memory.