Efectos de antagonistas selectivos y no selectivos a receptores 5-HT2C sobre la estructura de la conducta alimentaria en ratas

Abstract

It is known that the 5-HT2C receptors are involved in the regulation of food intake. Nevertheless, the relative role of selective and nonselective 5-HT2C receptor antagonists in the control of feeding behavior remains uncertain. In the present study, we examined the effects of serotonin (5-HT) on the feeding behavior patterns of rats pretreated with RS-102221 (5-HT2C receptor selective antagonist) or cyproheptadine (5-HT2C/2A receptor antagonist). The drugs were injected into the paraventricular hypothalamus nucleus (PVN). The animals were maintained in a self-selection feeding paradigm and provided with freely available and separate sources of protein, carbohydrate, fat, and water. The rats were kept at 21 ± 1°C on a 12 h light and 12 h dark cycle. Our results indicate that more selective 5-HT2C antagonists induce a major blockade of the hypophagic effect produced by 5-HT in the PVN. Both, selective and nonselective 5-HT2C receptors have shown participation in feeding behavior, mainly in the expression of satiation.