A teaching strategy for teaching stereochemistry: a proposal for converting from one representation to another
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The objective of this study was to develop a proposal for the teaching of stereochemistry to university chemistry and pharmacy students. The aim was to identify the representations of organic structures that are easiest for the students, using a didactic strategy for the identification, assignment of the absolute configuration and understanding of stereochemistry in the study of the stereochemistry of organic compounds. A scheme comprising different representations was presented to the students, with the relationships between them explained. This was done to facilitate interconversion and enable the students to correctly assign the configurations of the stereocentres. A pre-test was applied before the intervention, which involved Fischer projections, wedge and line formulas, Haworth and chair formulas. The results showed that only in Fischer projections and wedge and line formulas were the students able to assign the absolute configurations of the stereocentres. However, following the intervention, the students demonstrated the ability to perform interconversions in the Haworth and chair representations, resulting in an improvement in their performance from 0% to 65% and from 0% to 52.5%, respectively, in the case of wedges and lines the increase was from 22.2% to 60%, and from 81.3% to 100% for Fischer representations, indicating that the Fischer projection was the simplest representation for the assignment of the absolute configuration of the stereocentres.
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